Scientific Publications
An important asset of Memory Pharmaceuticals is the scientific capabilities of its scientific staff. The intellectual accomplishments and diversity of the staff are indicated by their publications in the fields of behavioral neuroscience, electrophysiology, cell signaling, medicinal chemistry, bioanalytics and pharmacokinetics. A selection of published scientific work from Memory Pharmaceuticals scientists is listed below.
Refereed Articles
2005
Chengjun Deng, Petro Halkowycz and Michael De Vivo. Assays for Cyclic Nucleotide-Specific Phosphodiesterases. In Current Protocols in Pharmacology 3.12.1-3.12.18, John Wiley and Sons (2005).
Tombaugh GC, Rowe WB, Rose GM. The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats. J Neurosci.25:2609-16. (2005)
Han-Ting Zhang, Ying Huang, Neesha U. Suvarna, Chengjun Deng, Alicia M. Crissman, Allen T. Hopper, Michael De Vivo, Gregory M. Rose and James M. O Donnell. Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats. Psychopharmacology (Berl). Jan 26; [Epub ahead of print] (2005)
2004
Voon S. Ong, Kevin L. Cook, Christine M. Kosara, William F. Brubaker Quantitative bioanalysis: an integrated approach for drug discovery and development. International Journal of Mass Spectrometry 238: 139–152 (2004).
Frankland PW, Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E, Silva AJ. Consolidation of CS and US representations in associative fear conditioning. Hippocampus. 14: 557-69. (2004)
Murphy GG, Fedorov NB, Giese KP, Ohno M, Friedman E, Chen R, Silva AJ. Increased neuronal excitability, synaptic plasticity, and learning in aged kvbeta1.1 knockout mice. Curr Biol. 14: 1907-15 (2004)
Egle I, Barriault N, Bordeleau M, Drage J, Dube L, Peragine J, Mazzocco L, Arora J, Jarvie K, Tehim A. N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists. Bioorg Med Chem Lett 14:4847-50 (2004).
Egle I, MacLean N, Demchyshyn L, Edwards L, Slassi A, Tehim A. -(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands.Bioorg Med Chem Lett. 14:727-9. (2004)
Ilch C.P., Golanov E.V. Cerebrovasodilation evoked by stimulation of subthalamic vasodilator area and hypoxia depends upon the integrity of cortical neurons in the rat. Neurosci. Lett. 368: 92-95. (2004).
2003
R.S. Martin, R.L. Secchi, E. Sung, M. Lemaire, D.W. Bonhaus, L.R. Hedley and D.A. Lowe : Effects of cannabinoid receptor ligands on rat models of psychosis. Psychopharmacology 165, 128-135 (2003).
Hering H, Sheng M.. Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. J. Neurosci. 23:11759-69. (2003)
Hering H, Lin CC, Sheng M. Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J. Neurosci. 23: 3262-71. (2003).
Glickstein S.B., Ilch C.P., and Golanov E.V. Electrical stimulation of the dorsal periaqueductal gray decreases volume of the brain infarction independently of accompanying hypertension and cerebrovasodilation. Brain Res. 994: 135-45. (2003).
Wang D, Deng C, Bugaj-Gaweda B, Kwan M, Gunwaldsen C, Leonard C, Xin X, Hu Y, Unterbeck A, De Vivo M. Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7. Cell Signal. 15: 883-91. (2003)
Isaac M, Slassi M, Xin T, Arora J, O'Brien A, Edwards L, MacLean N, Wilson J, Demschyshyn L, Labrie P, Naismith A, Maddaford S, Papac D, Harrison S, Wang H, Draper S, Tehim A. Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists. Bioorg Med Chem LettDec 13: 4409-13. (2003)
Egle I, MacLean N, Demchyshyn L, Edwards L, Slassi A, Tehim A. (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands. Bioorg Med Chem Lett. 13: 3419-21 (2003).
2002
Heyer J, Xiao Q, Bugaj-Gaweda B, Ramboz S, Unterbeck A. Conditional inactivation of the dopamine receptor 5 gene: flanking the Drd5 gene with loxP sites. Genesis. 32(2):102-4. (2002)
Tombaugh GC, Rowe WB, Chow AR, Michael TH, Rose GM. Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats. J Neurosci. 22(22):9932-40 (2002).
Kida S, Josselyn SA, de Ortiz SP, Kogan JH, Chevere I, Masushige S, Silva AJ. CREB required for the stability of new and reactivated fear memories. Nat Neurosci. 5:348-55. (2002)
Isaac MB, Xin T, O'Brien A, St-Martin D, Naismith A, MacLean N, Wilson J,Demchyshyn L, Tehim A, Slassi A. 1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles ashighly selective and potent 5-HT(7) receptor ligands. Bioorg Med Chem Lett.;12:2451-4. (2002)
Yau JL, Noble J, Hibberd C, Rowe WB, Meaney MJ, Morris RG, Seckl JR. Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats. J Neurosci.;22:1436-42. (2002)
Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 36: 493-505. (2002).
Rui M. Costa, Nikolai B. Fedorov, Jeffrey H. Kogan, Geoffrey G. Murphy, Joel Stern, Masuo Ohno, Raju Kucherlapati, Tyler Jacks & Alsino J. Silva. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 415: 526-530 (2002).
Auld D.S., Kornecook T.J., Bastianetto S. and Quirion R. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. Prog. Neurobiol. 68: 209-45. (2002).
2001
Atkinson BN, Bell SC, De Vivo M, Kowalski LR, Lechner SM, Ognyanov VI, Tham CS,Tsai C, Jia J, Ashton D, Klitenick MA. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol 60:1414-20 (2001).
Day J.C., Kornecook T.J. and Quirion R. Application of in vivo microdialysis to the study of cholinergic systems. Methods 23: 21-39. (2001).
Leaton, R.N., and Brucato, F.H., Startle Amplitude and Fear in an Acoustic Startle Paradigm: Lesions to the Brachium of the Inferior Colliculus or the Lateral Tegmental Pathway. Behavioral Neuroscience 115: 477-492. (2001).
2000
Sinnamon H.M., Jassen A.K., and Ilch C. Hippocampal theta activity and facilitated locomotor stepping produced by GABA injections in the midbrain raphe region. Behav. Brain Res. 107: 93-103. (2000).
K. Ramanathan, T. H. Michael, and P.A. Fuchs. Beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells. J. Neurosci. 20: 1675-1684. (2000).
Falls WA, Kogan JH, Silva AJ, Willott JF, Carlson S, Turner JG. Fear-potentiated startle, but not prepulse inhibition of startle, is impaired in CREBalphadelta-/- mutant mice. Behav Neurosci.. 114:998-1004. (2000)
Kogan JH, Frankland PW, Silva AJ. Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus. 10:47-56. (2000)
M. Eijkenboom, I. Gerlach, R. Jork, D. Lowe and F.J. van der Staay : Effects of subdural haematoma on sensorimotor functioning and spatial learning in rats. Neuropharmacology 39, 817-834 (2000)
R. Schreiber, D. Lowe, A. Voerste and J. De Vry : LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine. Eur. J. Pharmacol. 388, R3-R4 (2000).
1999
Kornecook T.J., Kippin T.E. and Pinel J.P. Basal forebrain damage and object-recognition in rats. Behav. Brain Res. 98: 67-76. (1999)
K. Ramanathan, T. H. Michael, G.-J. Jiang, H. Hiel, and P.A. Fuchs. A molecular mechanism for electrical tuning of cochlear hair cells. Science 283: 215-217. (1999).
Levin, E.D., Christopher, N. C., Weaver, T., Moore, J., Brucato, F.H. Ventral Hippocampal Ibotenic Acid Lesions Block Chronic Nicotine-Induced Spatial Working Memory Improvement in Rats. Cognitive Brain Research 7:3 405-10. (1999).
R. Schreiber, M. Dalmus, D. Lowe, and J. De Vry : No reversal of the phencyclidine-induced disruption of sensorimotor gating by the mGluR group II agonist, LY354740, in the rat. Behav. Pharm. 10 (suppl 1), S81 (1999).
1998
Leonard CJ, Aravind L, Koonin EV. Novel families of putative protein kinases in bacteria and archaea: evolution of the "eukaryotic" protein kinase superfamily. Genome Res. 8(10):1038-47. (1998)
Giese KP, Friedman E, Telliez JB, Fedorov NB, Wines M, Feig LA, Silva AJ. Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology. 2001 Nov; 41: 791-800.
Hopper, A.T.; Witiak, D.T.; Ziemniak, J., Design, Synthesis and Biological Evaluation of Stable Conformationally Constrained aci-Reductone Mimics of Arachidonic Acid. J. Med. Chem.41, 420-427. 1998
Giese KP, Storm JF, Reuter D, Fedorov NB, Shao LR, Leicher T, Pongs O, Silva AJ. Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem. 5: 257-73. 1998
Silva AJ, Giese KP, Fedorov NB, and Frankland PW, Kogan JH. Molecular, Cellular, and Neuroanatomical Substrates of Place Learning. Neurobiol Learn Mem. 70: 44-61. 1998
Giese KP, Fedorov NB, Filipkowski RK, Silva AJ. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science.; 279: 870-3. 1998
Tombaugh GC (1998) Intracellular pH buffering shapes activity-dependent Ca2+ dynamics in dendrites of CA1 interneurons. J. Neurophysiol. 80: 1702-1712.
1997
Kogan JH, Frankland PW, Blendy JA, Coblentz J, Marowitz Z, Schutz G, Silva AJ. Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol. 1;7(1):1-11. (1997)
Uetrecht J, Zahid N, Tehim A, Fu JM, Rakhit S. Structural features associated with reactive metabolite formation in clozapine analogues. Chem Biol Interact.;104(2-3):117-29. (1997)
Callahan PM, de la Garza R 2nd, Cunningham KA. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacol Biochem Behav. 1997 Jul;57: 601-7.
Fedorov NB, Brown RE, Reymann KG. Fast increases of AMPA receptor sensitivity following tetanus-induced potentiation in the CA1 region of the rat hippocampus. Neuroreport 8: 411-4. 1997
Tombaugh GC, Somjen GG (1997) Differential sensitivity to intracellular pH among high and low-threshold Ca2+ currents in isolated rat CA1 neurons. J. Neurophysiol. 77:639-653
1996
Brucato, F.H., Levin E.D., Mott D.D., Lewis D.L., Wilson W.A., Swartzwelder H.S., Long-Term Potentiation and Spatial Memory: The Effects of GABAB Receptor Blockade. Neuroscience 74:331-339. 1996
R. Buchet, E. Tavitian, D. Ristig, R. Swoboda, U. Stauss, H.U. Gremlich, L. de la Founière, M. Staufenbiel, P. Frey and D.A. Lowe : Conformations of synthetic ß peptides in solid state and aqueous solution: relation to neurotoxicity in PC12 cells. Biophys. Biochim. Acta. 1315, 40-46 (1996).
S. Urwyler, D. Laurie, D.A. Lowe, C.L. Meier and W. Müller : Biphenyl-derivatives of 2-Amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-Methyl-D-aspartate receptor antagonists - I. Pharmacological characterisation in Vitro. Neuropharmacology 35, 643-654 (1996).
W. Müller, P. Kipfer, D.A. Lowe and S. Urwyler : Syntheses of biphenyl analogues of AP7, a new class of competitive N-methyl-D-aspartate (NMDA) receptor antagonists. Helv. Chim. Acta. 78, 2026-2035 (1996).
S. Urwyler, D. Lowe, C. Meier and W. Müller : Biphenyl-AP7-derivatives, a new class of competitive N-methyl-D-aspartate receptor antagonists: in vitro pharmacology. J. Neurochem (Suppl) 65, S12C (1996).
1995
Hopper, A.T.; Witiak, D.T., Synthesis of Enantiomerically Pure Stereogenically Labile 4-Aryl-2-hydroxytetronic Acids from Enantiomerically Pure Silyl-protected Mandelaldehydes: aci-Reductone Analogues of Propionic Acid Non-Steroidal Anti-Inflammatory Agents. J. Org. Chem. 1995, 60, 3334-3341.
P. Hulley, J. Hartikka, S. Abdel'Al, P. Engels, H.R. Bürki, T. Müller, C. Goger, P. Kelly, D.A. Lowe and H. Lübbert : Inhibitors of Type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo. Eur. J. Neurosci. 7, 2431-2440 (1995).
Brucato, F.H., Mott, D.D., Lewis, D.V., Wilson W.A., Swartzwelder H.S., GABAB Receptors Modulate Synaptically Evoked Responses In Vivo. Brain Research 677:326-332. 1995.
1994
A.K. Dixon, C. Huber, and D.A. Lowe : Clozapine promotes approach-orientated behaviour in male mice. J. Clin. Psychiatry 55 (Suppl), 4-7 (1994).
Brucato, F.H., Levin, E.D., Rose, J.D., and Swartzwelder H.S., Intracerebroventricular Nicotine and Mecamylamine Alter Radial Arm Maze Performance in Rats. Drug Development Research 31:18-23. (1994).
C. Chengzhi, D. Buechler, D. Lowe, S. Urwyler and G. Shapiro : Synthesis of a pyrimidine isostere of the N-methyl-D-aspartate antagonist SDZ EAB 515. Tetrahedron 50, 5735-5740 (1994).
D.A. Lowe, M. Emre, P. Frey, P.H. Kelly, J. Malonowski, K.H. McAllister, H.C. Neijt, C. Rüdeberg, S. Urwyler, T.G. White and P.L. Herrling : The pharmacology of SDZ EAA 494 (D-CPPene), a competitive NMDA antagonist. Neurochem. Int. 25, 583-600. (1994).
Invited Lecturers
M. De Vivo, D. A.
Lowe : Emerging Therapies for Alzheimer’s Disease.
Neurodegeneration in Alzheimer’s Disease; Parkinson’s Disease &
Related Disorders (2005)
D. A. Lowe : Drosophila Neurological Disease Models Facilitate Drug Development. Abstract and Invited lecture: Society Chemical Industry, International Pharmaceutical Industry Conference,Edinburgh, Scotland, March 21-25 (2004).
D. A. Lowe : "Future Pain Drugs", invited session chair, SMI international meeting in London, 8-9 March 2000.
D. A. Lowe : "Behavioural deficits following subdural haematoma: a rat model for functional recovery after brain injury". International conference “Neuronal Plasticity: The Key to Stroke Recovery", Kananaskis, Alberta, Canada, 19-22 March 2000.
D. A. Lowe : "Neurotrophic factor research: potential impact on the treatment of neurological diseases". Invited panel discussant, Homburg/Saar, Germany. 7 October 1998.
D. A. Lowe : "Neuroscience research from an industrial perspective". European Neuroscience Study Group, European Commission, Science, Research and Development Directorate, Biotechnology. Brussels, Belgium 11 June 1998.
D.A. Lowe : "Clozapine promotes approach-orientated behavior in male mice". "Clozapine 1994". Garden City, New York, USA. February 25-26 1994.
Reviews
Hering H, Sheng M. 2001. Dendritic spines: structure, dynamics, regulation. Nat. Neurosci. 2(12): 880-8.
Silva AJ, Giese KP, Fedorov NB, Frankland PW, and Kogan JH. Molecular, cellular, and neuroanatomical substrates of place learning. Neurobiol Learn Mem. 70(1-2):44-61. (1998)
Tombaugh GC, Somjen GG (1998) pH modulation of voltage-gated ion channels, in (Kaila K., Ransom B., eds) pH Effects on Brain Function., John Wiley & Sons.
Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and memory. Annu Rev Neurosci. 21:127-48. (1998) Silva AJ, Fedorov N, Kogan J, Frankland P, Coblentz J, Lundsten R, Friedman E, Smith A, Cho Y, Giese KP. Genetic analysis of function and dysfunction in the central nervous system. Cold Spring Harb Symp Quant Biol. 1996; 61:239-46.
De Vivo, M. Assays for G protein regulation of phospholipase C activity, in Methods in Enzymology, vol. 238 (R. Iyengar, editor), Academic Press, Inc. San Diego, CA, pp. 131-140, 1994.
De Vivo, M. and M.C. Gershengorn. G proteins and phospholipid turnover, in ADP-Ribosylating Toxins and G Proteins: Insights into Signal Transduction (J. Moss and M. Vaughan, eds.), American Society for Microbiology, Washington, D.C., pp. 267-293, 1990.
De Vivo, M. and S. Maayani. 5-HT receptors coupled to adenylate cyclase, in The Serotonin Receptors (E. Sanders-Bush, ed.), Humana Press, Clifton, NJ, pp. 141-179, 1988.
Posters and Abstracts
Society for Neuroscience Annual Meeting, 2005
"Effects of Donepezil And Rolipram on Scopolamine Induced Deficits
in Context Fear Conditioning and The Radial Arm Maze in Rats"
D.F.
Fiorino* and F.H. Brucato
"PDE4 Inhibitor Affinity At The High Affinity Rolipram Binding Site
(HARBS) Predicts Efficacy In The Rat Pup Ultrasonic Vocalization Model
."
F.H Brucato*, A. Hopper, K. Cook, B. Chanas, C. Deng, and D.F.
Fiorino
Society for Neuroscience Annual Meeting, 2004
"Temporal Order Discrimination in Young and Aged Sprague-Dawley Rats"
C. Trippodi, G.M. Rose
"Pre-Training Lesions of the Dorsal Hippocampus Impair Both Spatial
and Non-Spatial Memory in Mice."
Brucato, F.H., Kogan, JH. McNicholas K, Rose G.M., Kliteneck, Brunner, D.,
International Conference on AD (2004)
"Differential Decline of Memory Systems During Aging"
C. Trippodi, G.M. Rose
Society for Neuroscience Annual Meeting, 2003
"Enduring Effect of a Nicotinic a7 Receptor Agonist, AR-R 17779 on
Spatial Learning Ability in Aged F344 Rats"
WB Rowe, CP Ilch, K Solomon and GM Rose
"Characterization of Nicotinic a7 Receptor Agonists in Animal
Models of Cognition"
PM Callahan, KL McNicholas, C. Ilch, WB Rowe, FH Brucato, JH Kogan and
GM Rose
"Object Recognition and Object Location Memory in Young and Aged
Sprague-Dawley Rats"
C Trippodi, GM Rose
"Phosphodiesterase 4D7 Interacts with the Light Chain Domains of
Microtubule-Associated Protein 1A and 1B"
MY Kwan, B Clark, M De Vivo and D Wang
"Calcium Spikes are Enhanced Selectively in Aged F344 Rats With
Performance Deficits in the Morris Water Maze"
GC Tombaugh, WB Rowe, GM Rose
"Context Fear and Morris Water Maze Performance Identifies Similar
Populations of Memory Impaired or Unimpaired Aged F344 Rats"
FH Brucato, WB Rowe, CP Ilch, GM Rose
SRI Conference: Phosphodiesterases in Disease, October 2003
"PDE4 as a Potential Therapeutic Target for Impaired Cognition"
M De Vivo
51st Annual ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Canada, June 8-12, 2003
"An Investigation of Protein Binding Using Ultrafiltration and
TFC-LC/MS/MS."
KL Cook, VS Ong, WF Brubaker
"Quantitative Analysis of Dihydropyridines in Plasma and Tissue
Using Turbulent Flow Chromatography/Tandem Mass Spectrometry"
CM Kosara, VS Ong, Kevin L. Cook, William F. Brubaker
2002 Society for Neuroscience Annual Meeting, Orlando, FL, November 2-6, 2002
"Evaluation of MEM 1414 in Novel Object Recognition Memory"
C Trippodi, GM Rose
"The Slow After-Hyperpolarization (sAHP) in CA1 Neurons Correlates
with Spatial Learning Ability in Aged F344 Rats"
GC Tombaugh, WB Rowe, GM Rose
"Effects of the Novel PDE4 Inhibitors MEM1018 and MEM1091 in Models
of Memory and Antidepressant Sensitivity"
HT Zhang, Y Huang, NU Suvarna, AM Crissman, AT Hopper, M DeVivo, GM
Rose, JM O'Donnell
50th Annual ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, June1-6, 2002
"Integrated Bioanalytical Support Using Turbulent-Flow
Chromatography-Mass Spectrometry."
VS Ong, KL Cook, CM Kosara, J Bernstein, WF Brubaker
7th Annual Duke Nicotine Research Conference, 2001
Abstract:
"The effects of aging and nicotine in Novel Object Recognition memory
in rats"
FH Brucato, WB Rowe, GM Rose
2000 Society for Neuroscience Annual Meeting, New Orleans, LA, November 4-9, 2000
Poster:
"Identification Of Age-Related Deficits in Novel Object Recognition
Memory In Rats"
FH Brucato, WB Rowe, GM Rose
Poster:
"Characterization of Novel Object Recognition (NOR) in Young,
Adolescent, and Aged Male C57BL/6 Mice"
C Trippodi, RM Gordon, GM Rose
Poster:
"LTP induced in CA1 by Theta Frequency Stimulation In Vitro
Distinguishes Learning-impaired From Unimpaired Aged Rat"
GC Tombaugh, WB Rowe, A Chow, T Michael, GM Rose
"Potentiation of MK-801-induced locomotor activity by 5HT1B receptor
agonists in the rat."
D.A. Lowe, S.N. Mitchell, C. Perren and D. Bonfils
"BAY 36-7620, a selective metabotropic glutamate receptor1 (mGLUR1)
antagonist with anticonvulsant and neuroprotective properties."
Th. Müller, J. De Vry, R. Schreiber, E. Horvath, F. Mauler, A.
Stolle and D. Lowe
Stroke Recovery Conference, March 19-22, 2000. Kananaskis, Canada.
"Behavioral deficits in a rat model for functional recovery after
brain injury are ameliorated by acute neuroprotection with Repinotan."
I. Gerlach, M. Eijkenboom, E. Horvath, F.-J. van der Staay, R. Jork and
D. Lowe :