Montvale, NJ – March 5, 2007 - Memory Pharmaceuticals Corp. (NASDAQ: MEMY) today announced top-line data from the Phase 2a study of MEM 1003 in acute mania in bipolar disorder, which was conducted with funding support from the Stanley Medical Research Institute. An analysis of the primary and secondary outcome measures in the trial indicated that MEM 1003 did not prove effective for the treatment of bipolar mania. MEM 1003 was safe and generally well-tolerated in the study.
The multi-center, double-blind, randomized, placebo-controlled study evaluated the
safety and efficacy of MEM 1003 for the treatment of acute mania in bipolar
disorder. Eighty-four subjects were randomized to receive MEM 1003 or placebo
for a 21-day treatment period, which was followed by an optional open-label
four-week treatment period. The primary outcome measure was a comparison of the
percentage of subjects in the placebo and MEM 1003 treatment groups with at
least 50% improvement from baseline in the Young Mania Rating Scale (YMRS) at
21 days. The secondary outcome measures were the mean change from baseline in
the YMRS, the Modified Clinical Global Impression – Bipolar Scale and the
Montgomery-Åsberg Depression Rating Scale at 21 days. None of these outcome
measures was achieved.
There were no serious adverse events reported in the MEM 1003 treatment group during the
study, in contrast to three serious adverse events of worsening of mania
reported in the placebo treatment group. The most commonly reported adverse
events in the MEM 1003 treatment arm of the trial were headache,
gastrointestinal effects and pruritus (or itching).
"We are obviously disappointed that MEM 1003 did not prove effective in the treatment of
mania in our study,” said Stephen R. Murray, M.D., Ph.D., Vice President of
Clinical Development. “However, the target symptoms and the nature of the
assessments in our ongoing Phase 2a study in Alzheimer’s disease are very
different from those in this mania study, and we do not believe that the
negative results in this study are predictive of the effects of MEM 1003 in
Alzheimer’s disease."
"Memory Pharmaceuticals has completed a high quality study,” said Gary S. Sachs, M.D.,
Associate Professor in Psychiatry, Harvard Medical School and Director, Bipolar
Mood Disorder Program at Massachusetts General Hospital and Principal
Investigator on the Phase 2a trial of MEM 1003 in bipolar disorder. “Although
the maximum dose allowed in the study proved well-tolerated, the results
clearly showed no difference in efficacy endpoints at day 21 between MEM 1003
and placebo."
"We are committed to finishing the ongoing Phase 2a study in Alzheimer’s disease and
expect results in the fourth quarter of this year,” said David A. Lowe, Ph.D.,
Chief Scientific Officer. “We are currently completing a full analysis of the
bipolar results in order to learn as much as we can from this data set."
About MEM 1003
MEM 1003, a CNS-optimized dihydropyridine, is a neuronal L-type calcium channel
modulator. MEM 1003 was found to be generally safe and well tolerated in Phase
1a and 1b clinical trials in 125 healthy volunteers in the United Kingdom and a
Phase 1b safety and tolerability study in 81 Alzheimer’s patients under a U.S.
Investigational New Drug Application. The Company is currently conducting a
multi-center, randomized, double-blind, placebo-controlled Phase 2a study to
evaluate the safety and efficacy of MEM 1003 in Alzheimer’s disease.
Conference Call and Webcast Information
Memory Pharmaceuticals will hold a conference call on Monday, March 5, 2007, at 9:00
a.m. EST to discuss the top-line data from the Phase 2a bipolar trial of MEM
1003. The conference call will also be broadcast live from the "Investors"
section of the Company's website. Memory Pharmaceuticals' senior management
will host the conference call. Investors and other interested parties may
access the call as follows:
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Date: Monday, March 5, 2007
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Time: 9:00 a.m. EST
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Telephone (U.S.): 866.800.8651
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Telephone (international): 617.614.2704
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Participant Passcode: 50292952
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Webcast: http://www.memorypharma.com under the "Investors" section
An audio replay of the conference call will be available from 11:00 a.m. EST on Monday, March 5, 2007, until
Monday, March 12, 2007. To access the replay, please dial 888.286.8010 (U.S.)
or 617.801.6888 (international) and enter passcode number 74112194. An audio
replay of the conference call will also be available under the "Investors"
section of the Company's website during the same period.
About the Company
Memory Pharmaceuticals Corp., a biopharmaceutical company, is focused on developing innovative drugs for the
treatment of debilitating CNS disorders such as Alzheimer's disease,
schizophrenia, depression and bipolar disorder. For additional information,
please visit our website at http://www.memorypharma.com.
Safe Harbor Statement
This press release contains forward-looking statements within the meaning of the Private Securities Litigation
Reform Act of 1995 that are subject to risks and uncertainties. All statements,
other than statements of historical facts, regarding management's expectations,
beliefs, goals, plans or Memory Pharmaceuticals’ prospects, future financial
position, future revenues and projected costs should be considered
forward-looking. Readers are cautioned that actual results may differ
materially from projections or estimates due to a variety of important factors,
including the risks and uncertainties associated with: obtaining additional
financing to support Memory Pharmaceuticals' R&D and clinical activities and
operations; conducting preclinical and clinical trials of Memory
Pharmaceuticals’ drug candidates that demonstrate these candidates' safety and
effectiveness; receiving unfavorable results from clinical trials of Memory
Pharmaceuticals’ drug candidates; obtaining regulatory approvals to conduct
clinical trials and to commercialize Memory Pharmaceuticals’ drug candidates;
Memory Pharmaceuticals’ ability to enter into and maintain collaborations with
third parties for its drug development programs; Memory Pharmaceuticals’
dependence on its collaborations and its license relationship with Bayer;
achieving milestones under Memory Pharmaceuticals’ collaborations; Memory
Pharmaceuticals’ dependence on third-party preclinical or clinical research
organizations, manufacturers and consultants; and protecting the intellectual
property developed by or licensed to Memory Pharmaceuticals. These and other
risks are described in greater detail in Memory Pharmaceuticals’ filings with
the Securities and Exchange Commission. Memory Pharmaceuticals may not actually
achieve the goals or plans described in its forward-looking statements, and
investors should not place undue reliance on these statements. Memory
Pharmaceuticals disclaims any intent or obligation to update any
forward-looking statements as a result of developments occurring after the date
of this press release.
SOURCE Memory Pharmaceuticals Corp.
http://www.memorypharma.com/
